Impaired Insulin-Induced Glucose Uptake by Extrahepatic Tissue Is Hallmark of NIDDM Patients Who Have or Will Develop Hypertension and Microalbuminuria

75 non-insulin-dependent diabetes mellitus (NIDDM) patients and 20 normal control subjects from an outpatient clinic in Padua, Italy. NIDDM patients were divided into 4 groups based on blood pressure (>145/90 mmHg) and albumin excretion rate (>20 μg/min): 28 normotensive normoalbuminuric, 19 hypertensive normoalbuminuric, 15 normotensive microalbuminuric, and 13 hypertensive microalbuminuric.

Insulin-induced whole-body glucose utilization, hepatic glucose output, and development of hypertension and microalbuminuria over 6 yearssurrogate