May 1, 1998Diabetes
Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study.
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Discussion
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Implication
Cross-sectional analysis finds lower insulin sensitivity linked to microalbuminuria in nondiabetic adults, suggesting metabolic dysfunction precedes overt vascular damage.
Key Points
- To investigate the cross-sectional relationship between insulin sensitivity, fasting insulin levels, and microalbuminuria in nondiabetic adults.
- Cross-sectional analysis of 982 nondiabetic participants aged 40–69 years from the Insulin Resistance Atherosclerosis Study.
- Insulin sensitivity was measured using a frequently sampled intravenous glucose tolerance test with minimal model analysis.
- Microalbuminuria was defined as an albumin-to-creatinine ratio ≥ 2 mg/mmol, evaluated alongside fasting insulin and clinical covariates.
- Microalbuminuria was present in 15% of participants, who showed lower insulin sensitivity compared to those without it (1.70 ± 0.11 vs. 2.25 ± 0.07 × 10⁻⁴ min⁻¹·μU⁻¹·ml⁻¹, P = 0.003).
- Higher insulin sensitivity was associated with reduced odds of microalbuminuria (OR = 0.86, 95% CI: 0.79–0.94, P < 0.001).
- The significant inverse association persisted after adjusting for age, sex, ethnicity, hypertension, fasting glucose, and BMI, across both normotensive and hypertensive groups.
Cite This Study
Mykkänen et al. (1998) studied this question.