Human Tissue Valves in Aortic Position
Key result
Subcoronary implantation of human tissue valves resulted in more initial aortic regurgitation and early reoperation compared with root replacement.
Why the study?
Does subcoronary implantation compared to root replacement affect aortic regurgitation and reoperation in adults receiving human tissue valves?
Population
299 adult patients undergoing aortic valve replacement with human tissue valves.
Comparison
Subcoronary implantation technique for aortic… vs Root replacement technique using aortic…
Design
Cohort
Follow-up
Mean 4.2 years (SD 2.7; range, 0 to 10.5)
Authors
Discussion
Loading...
Member takes
Implication
May warrant root replacement preference to limit early regurgitation and reoperation; leaves open optimal technique selection in randomized trials.
Study Design
Type
Cohort (n=299)
Structured PICO
Does subcoronary implantation compared to root replacement affect aortic regurgitation and reoperation in adults receiving human tissue valves?
P
Population
299 adult patients undergoing aortic valve replacement with cryopreserved aortic allografts or pulmonary autografts, followed for a mean of 4.2 years.
E
Exposure
Subcoronary implantation technique for aortic valve replacement (n=85)
C
Comparator
Root replacement technique using aortic allografts (n=133) or pulmonary autografts (n=81)
O
Outcome
Aortic valve regurgitation measured by serial color Doppler echocardiography (jet length method and jet diameter ratio) and need for reoperationsurrogate
Subcoronary implantation of human tissue valves is associated with a learning curve and more initial regurgitation, though long-term progression is similar to root replacement and is primarily accelerated in young adults.
Cite This Study
Willems et al. (2001) conducted a cohort in Aortic valve replacement (n=299). Subcoronary implantation vs. Root replacement was evaluated on Aortic regurgitation and reoperation. Subcoronary implantation of human tissue valves resulted in more initial aortic regurgitation and early reoperation compared with root replacement.