Key result
Low-dose bisoprolol treatment for 4 weeks achieved the treatment goal of >70% PVC reduction and symptom relief in 50% of hypertensive patients with LVH (p < 0.05).
Why the study?
Premature ventricular contractions are more frequent in hypertensive patients with left ventricular hypertrophy, but the effect of bisoprolol on these arrhythmias in Vietnamese patients needed evaluation.
Does bisoprolol reduce premature ventricular contractions in hypertensive patients with left ventricular hypertrophy?
Observational (n=50)
No
Does bisoprolol reduce premature ventricular contractions in hypertensive patients with left ventricular hypertrophy?
Low-dose bisoprolol effectively reduces the burden of premature ventricular contractions and associated symptoms in hypertensive patients with left ventricular hypertrophy.
BACKGROUND: Premature ventricular contraction (PVC) is a common arrhythmia that causes a large number of clinical symptoms, adversely impacts the quality of life, and can even initiate serious arrhythmias, such as ventricular tachycardia or ventricular fibrillation. The incidence of premature ventricular contraction is higher in hypertensive patients, particularly if concomitant left ventricular hypertrophy (LVH) is present. OBJECTIVES: This study was conducted on the characteristics of PVC in hypertensive patients with left ventricular hypertrophy and aimed to evaluate the effect of bisoprolol on PVC in Vietnamese patients with hypertension and LVH. MATERIALS AND METHODS: We conducted a study to determine how bisoprolol potency affected PVC management in the group with both high blood pressure and LVH. We selected a convenient sample of all patients who came to the Medical Examination Department at the Can Tho University of Medicine and Pharmacy Hospital and met sampling criteria with hypertension, LVH on echocardiography, and PVC on 12-leads electrocardiogram. Over 2 years, we collected 76 patients who satisfied the above conditions. Out of which, 50 patients were indicated for management with bisoprolol, and 26 patients were excluded from the study, including 7 patients with asthma and 19 patients who had simple PVC on a 24-hour Holter ECG. Data were analyzed with SPSS version 22. RESULTS: Fifty patients participated in the study, of whom 70% were female. It is clear that palpitation was the most prevalent symptom (66%), and 38% of patients had complicated PVC (Lown III-V). When treating PVC with bisoprolol, 50% of patients achieved the treatment goal with a decrease in the number of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs. After 4 weeks of treatment, bisoprolol decreased the number of PVCs, heart rate, and blood pressure while also easing PVC-related symptoms (p < 0.05). CONCLUSION: Low-dose bisoprolol effectively reduces the number of PVCs in hypertensive patients with LVH.
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Tran et al. (2023) conducted an observational in Hypertension with left ventricular hypertrophy and premature ventricular contractions (n=50). Bisoprolol was evaluated on Treatment goal achievement (decrease in the number of PVCs of more than 70%, accompanied by symptom relief and eradication of dangerous PVCs) (p=<0.05). Low-dose bisoprolol treatment for 4 weeks achieved the treatment goal of >70% PVC reduction and symptom relief in 50% of hypertensive patients with LVH (p < 0.05).
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