When using supercritical fluid extraction (SFE), a variety of chemical and physical parameter interactions must be considered in developing a sample preparation method. Those interactions, especially for an analyst who is unfamiliar with the properties and potentials of supercritical fluids, can make routine analytical method development quite rigorous. This paper is meant as a guide for a novice user of SFE. It illustrates a logical scheme to consider when removing an analyte from a difficult matrix.
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Mary McNally (1996) studied this question.