Key result
NO/nucleophile adducts induce endothelium-independent vasodilation by releasing NO, with duration of action controllable by structural modification (DEA/NO peaked at 5 min vs SPER/NO at 15 min).
NO/nucleophile adducts induce vasodilation by spontaneously releasing NO to activate guanylate cyclase, with duration of action controllable by structural modification.
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May enable tailored NO donor design for vasodilation; leaves open clinical translation from animal models.
Morley et al. (1993) studied this question. NO/nucleophile complexes (DEA/NO and SPER/NO) vs. Inhibitors and structural variants was evaluated on Vasorelaxation and duration of action. NO/nucleophile adducts induce endothelium-independent vasodilation by releasing NO, with duration of action controllable by structural modification (DEA/NO peaked at 5 min vs SPER/NO at 15 min).
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