Key result
Intravenous injections of diazeniumdiolate NO* donors caused dose-dependent decreases in systemic arterial pressure and hindquarters perfusion pressure in cats.
Why the study?
Do diazeniumdiolate NO* donors decrease systemic arterial and hindquarters perfusion pressure in a cat model?
Do diazeniumdiolate NO* donors decrease systemic arterial and hindquarters perfusion pressure in a cat model?
Diazeniumdiolate NO donors act as endothelium-independent vasodilators that directly stimulate soluble guanylate cyclase to decrease vascular resistance.
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Supports vasodilator investigation in feline models; leaves open translation to human cardiovascular therapy.
Bivalacqua et al. (2001) studied this question. Diazeniumdiolate NO* donors was evaluated on Systemic arterial pressure and hindquarters perfusion pressure. Intravenous injections of diazeniumdiolate NO* donors caused dose-dependent decreases in systemic arterial pressure and hindquarters perfusion pressure in cats.
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