Key result
Exposure to normobaric hyperoxia (FiO2 0.4) in healthy full-term pregnant women significantly reduced cardiac index from 3.18 to 3.03 L/min/m2 (p=0.004).
Why the study?
Does normobaric hyperoxia alter haemodynamic parameters in healthy full-term parturients?
Does normobaric hyperoxia alter haemodynamic parameters in healthy full-term parturients?
A moderate increase in inspired oxygen fraction (F(I)o(2) 0.4) significantly reduces cardiac index and increases systemic vascular resistance in healthy full-term pregnant women.
May warrant caution with supplemental O2 in term pregnancy; leaves open effects during labor or in high-risk parturients.
Fifteen healthy, full-term women with singleton pregnancies were exposed to an increased F(I)o(2) of 0.4 and their haemodynamic responses measured with a non-invasive transthoracic bio-impedance monitor. There was a mean reduction in cardiac index from 3.18 to 3.03 l x min(-1) x m(-2) (4.7%, p = 0.004). The mean indexed systemic vascular resistance increased from 2049 to 2178 dynes x cm(-5) x m(-2) (5.7%, p = 0.005). There were no significant changes in stroke index, heart rate or mean arterial pressure. This study demonstrates that even a moderate increase in inspired oxygen fraction has significant effects on the cardiovascular system of the term parturient.
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Litchfield et al. (2007) studied healthy, full-term pregnancy (n=15). normobaric hyperoxia vs. baseline was evaluated on cardiac index (4.7% reduction, p=0.004). Exposure to normobaric hyperoxia (FiO2 0.4) in healthy full-term pregnant women significantly reduced cardiac index from 3.18 to 3.03 L/min/m2 (p=0.004).
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