Key result
Takotsubo syndrome is a stress-induced condition resembling acute myocardial infarction that carries a higher mortality than previously thought and requires prompt management of acute complications.
This review summarizes current knowledge on the pathophysiology, diagnosis, and management of Takotsubo syndrome, highlighting that its mortality is higher than previously thought.
Challenges initial view of benign prognosis in Takotsubo syndrome; leaves open risk stratification for long-term follow-up.
Takotsubo syndrome was first described in Japan in 1990. Although it has gained worldwide recognition in the last 25 years, the pathophysiology of Takotsubo syndrome remains controversial. This syndrome is often reported in elderly postmenopausal women suffering from sudden, unexpected emotional and physical stress. Its clinical presentation resembles that of acute myocardial infarction. The prognosis of Takotsubo syndrome was initially considered favorable compared with that of myocardial infarction; however, subsequent studies have demonstrated that the mortality was higher than previously reported. Prompt diagnosis followed by appropriate management for acute complications such as heart failure, arrhythmia, intraventricular thrombus, and left ventricular outflow tract obstruction is required. We discuss the current knowledge on Takotsubo syndrome to facilitate optimal diagnosis and treatment.
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Tanabe et al. (2016) conducted a review in Takotsubo syndrome. Takotsubo syndrome is a stress-induced condition resembling acute myocardial infarction that carries a higher mortality than previously thought and requires prompt management of acute complications.
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