Key result
Nissen fundoplication was associated with an abnormally low plasma pancreatic polypeptide response to insulin hypoglycaemia in 29% of patients (p<0.05), suggesting potential vagal damage.
Why the study?
Does Nissen fundoplication result in abnormal plasma pancreatic polypeptide responses to insulin hypoglycaemia compared to controls?
Population
59 subjects total: 24 patients with Nissen fundoplication, 9 non-operated patients with severe…
Comparison
Intravenous injection of 0.1 U/kg insulin to… vs Normal control subjects, non-operated GORD…
Design
Cohort
Authors
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May indicate vagal injury risk after Nissen fundoplication; leaves open long-term clinical impact and need for technique modification.
Observational (n=59)
Does Nissen fundoplication result in abnormal plasma pancreatic polypeptide responses to insulin hypoglycaemia compared to controls?
Absolute Event Rate: 29% vs 0%
p-value: p=< 0.05
Patients with Nissen fundoplication often exhibit abnormal plasma pancreatic polypeptide responses to insulin hypoglycaemia, suggesting potential vagal damage during surgery.
Jansen et al. (1989) conducted an observational in Gastro-oesophageal reflux disease (GORD) (n=59). Nissen fundoplication vs. Non-operated GORD patients and normal controls was evaluated on Plasma pancreatic polypeptide (PP) response to insulin hypoglycaemia below the lowest value in control subjects (p=< 0.05). Nissen fundoplication was associated with an abnormally low plasma pancreatic polypeptide response to insulin hypoglycaemia in 29% of patients (p<0.05), suggesting potential vagal damage.
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