Why the study?
Do subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia predict the development of overt autonomic neuropathy in patients with insulin-dependent diabetes mellitus?
Population
16 patients with insulin-dependent diabetes mellitus with no current evidence of autonomic dysfunction, and…
Comparison
Subnormal plasma pancreatic polypeptide and… vs Normal plasma pancreatic polypeptide and…
Design
Cohort
Follow-up
2 to 3 years
Authors
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Subnormal responses may flag neuropathy risk in IDDM; leaves open whether testing alters management or outcomes.
Do subnormal pancreatic polypeptide and epinephrine responses to insulin-induced hypoglycemia predict the development of overt autonomic neuropathy in patients with insulin-dependent diabetes mellitus?
Diminished pancreatic polypeptide and epinephrine responses to hypoglycemia can predict the development of overt autonomic neuropathy in patients with insulin-dependent diabetes mellitus.
Frank P. Kennedy (1988) studied this question.
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