Key result
Autonomic neuropathy in juvenile diabetics was associated with a severely impaired pancreatic polypeptide response to insulin-induced hypoglycaemia (22 pmol/l vs 252 pmol/l without neuropathy).
Why the study?
Does the pancreatic polypeptide response to insulin-induced hypoglycaemia indicate autonomic neuropathy in juvenile diabetics?
Observational (n=18)
Does the pancreatic polypeptide response to insulin-induced hypoglycaemia indicate autonomic neuropathy in juvenile diabetics?
Impaired secretion of pancreatic polypeptide in response to hypoglycaemia may serve as an early sign of autonomic neuropathy in diabetes.
Answers are grounded in this paper and cite their sources.
May signal autonomic neuropathy in juvenile diabetes; hypothesis-generating pending prospective validation.
The pancreatic polypeptide (PP) response to insulin-induced hypoglycaemia was studied in 18 juvenile diabetics and was calculated as the difference between the prestimulatory PP concentration and the maximal concentration measured. The response was severely impaired in patients with autonomic neuropathy (mean +/- SE of mean 22 +/- 12 pmol/l) as compared with patients without neuropathy (252 +/- 51 pmol/l). Patients whose diabetes was of only a few years' duration showed a normal PP response to hypoglycaemia, and the response diminished significantly with increasing duration of diabetes. The decreased PP response to hypoglycaemia was significantly correlated with an increased threshold of the sense of vibration, (rs = 0.86). These results suggest that impaired, secretion of PP may serve as an early sign of autonomic neuropathy in diabetes.
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Krarup et al. (1979) conducted an observational in Juvenile diabetes (n=18). Autonomic neuropathy vs. No autonomic neuropathy was evaluated on Pancreatic polypeptide (PP) response to insulin-induced hypoglycaemia. Autonomic neuropathy in juvenile diabetics was associated with a severely impaired pancreatic polypeptide response to insulin-induced hypoglycaemia (22 pmol/l vs 252 pmol/l without neuropathy).
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