Key result
Diabetics with autonomic neuropathy exhibited an impaired human pancreatic polypeptide response to insulin-induced hypoglycemia (654 pg/ml) compared to normal controls (3020 pg/ml).
Why the study?
Does insulin-induced hypoglycemia elicit different human pancreatic polypeptide responses in diabetics with autonomic neuropathy compared to those without and normal controls?
Population
15 subjects: normal controls, age- and weight-matched diabetics with clinical evidence of autonomic…
Comparison
Insulin-induced hypoglycemia vs Normal controls and diabetics without autonomic…
Design
Case-control
Authors
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Impaired response may reflect vagal dysfunction; hypothesis-generating and should not yet change practice.
Observational (n=15)
Does insulin-induced hypoglycemia elicit different human pancreatic polypeptide responses in diabetics with autonomic neuropathy compared to those without and normal controls?
Absolute Event Rate: 654% vs 3020%
Diabetic autonomic neuropathy is associated with an impaired human pancreatic polypeptide response to insulin-induced hypoglycemia.
Levitt et al. (1980) conducted an observational in Diabetic Autonomic Neuropathy (n=15). Diabetic Autonomic Neuropathy vs. Normal controls and diabetics without autonomic neuropathy was evaluated on Human pancreatic polypeptide (hPP) response to insulin-induced hypoglycemia. Diabetics with autonomic neuropathy exhibited an impaired human pancreatic polypeptide response to insulin-induced hypoglycemia (654 pg/ml) compared to normal controls (3020 pg/ml).
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