Key result
A high-fat plus fructose diet in rats elevated blood pressure, metabolic markers, and vasoconstrictor prostanoids, producing deleterious effects greater than either treatment alone.
A combined high-fat and fructose diet in rats induces metabolic syndrome-like alterations and shifts vascular prostanoid production towards vasoconstrictors, contributing to hypertension.
HF+F diet effects on rat mesenteric prostanoids remain hypothesis-generating; leaves open translation to human metabolic syndrome therapies.
In the rat, a high-fat (HF) plus fructose (F) diet produces cardiovascular and metabolic alterations that resemble human metabolic syndrome. Prostanoids (PR), cyclo-oxygenase-derived arachidonic acid metabolites, have vasoactive properties and mediate inflammation. The aim of this study was to analyse the effect of a HF+F diet on blood pressure (BP), metabolic parameters and mesenteric vascular bed PR production in male Sprague-Dawley rats. Four groups were studied over 9 weeks (n = 6 each): control (C), standard diet (SD) and tap water to drink; F+SD and 10% w/v F solution to drink; HF 50% (w/w) bovine fat added to SD and tap water; and HFF, both treatments. PR were determined by HPLC. Blood pressure was elevated in all experimental groups. Triglyceridaemia, insulinaemia and HOMA-IR were increased in the F and HF groups. HF+F animals showed elevated glycaemia, insulinaemia, HOMA-IR and triglyceridaemia. F decreased the vasodilator prostanoids PGI2 and PGE2 in the mesenteric vascular bed. Body weight was not significantly altered. In HFF, production of PGE2 , PGF2 alpha and TXB2 was elevated. The increased BP in HF and HFF could be partly attributed to the imbalance in vascular PR production towards vasoconstrictors. On the other hand, this dietary modification could induce inflammation, which would explain the elevation of PGE2 . In the F group, hypertension could be related to decreased vasodilator PRs. The simultaneous administration of HF and F in the rat produces deleterious effects greater than observed when treatments are applied separately.
No takes yet. Share an insight, caveat, or question.
Peredo et al. (2015) studied Metabolic syndrome model (n=24). High-fat plus fructose diet vs. Standard diet and tap water (Control), Fructose alone, High-fat alone was evaluated on Blood pressure, metabolic parameters and mesenteric vascular bed prostanoid production. A high-fat plus fructose diet in rats elevated blood pressure, metabolic markers, and vasoconstrictor prostanoids, producing deleterious effects greater than either treatment alone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: