Key result
A 3-week fructose-rich diet in rats induced significant changes in perivascular adipose tissue fatty acid composition and oxidative stress, which impaired its paracrine ability to attenuate serotonin-induced vascular contraction.
Why the study?
Does a 10% fructose-rich diet alter perivascular adipose tissue composition and vascular contractility in adult male Wistar rats?
Population
Adult male Wistar rats weighing 180-200 g
Comparison
10% fructose added to drinking water for 3 weeks vs Standard laboratory rat diet and tap water for 3…
Design
Preclinical, Rats were divided into two groups
Follow-up
3 weeks
Authors
Loading...
May precede vascular dysfunction in metabolic syndrome; leaves open whether perivascular adipose tissue targeting alters human outcomes.
Does a 10% fructose-rich diet alter perivascular adipose tissue composition and vascular contractility in adult male Wistar rats?
A fructose-rich diet induces early alterations in the paracrine function of perivascular adipose tissue, preceding changes in vascular smooth muscle function, which may contribute to vascular dysfunction in metabolic syndrome.
Rebolledo et al. (2010) studied Metabolic syndrome / Insulin resistance model. Fructose-rich diet vs. Control diet with tap water was evaluated on Vascular contractility and perivascular adipose tissue (PVAT) oxidative stress/lipid composition. A 3-week fructose-rich diet in rats induced significant changes in perivascular adipose tissue fatty acid composition and oxidative stress, which impaired its paracrine ability to attenuate serotonin-induced vascular contraction.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: