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January 1, 1994Blood Coagulation & Fibrinolysis

Strategies for inhibiting the effects of thrombin

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Authors

LHLaurence A. Harker

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Overview

May overcome heparin resistance in select thrombotic settings; leaves open confirmation of net clinical benefit in prospective trials.

Structured PICO

I
Intervention
Thrombin inhibitors (heparin, hirudin, synthetic antithrombin peptides)

Antithrombin-independent direct thrombin inhibitors can overcome heparin resistance by inactivating both soluble and thrombus-bound thrombin.

Cite This Study

Laurence A. Harker (1994) studied this question.

synapsesocial.com/papers/6a996488e8ca4d2af6364e92https://doi.org/10.1097/00001721-199401000-00007
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Also Consider

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  1. 1Influence of Thrombin Inhibitors on the Thrombin-Induced Activation of Human Blood Platelets2009 · 19 citations
  2. 2Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation1997 · 72 citations
  3. 3Inhibition of thrombin: relevance to anti-thrombosis strategy2006 · 9 citations
  4. 4Natural inhibitors of thrombin2014 · 54 citations
  5. 5Inhibition of clot-bound and free (fluid-phase thrombin) by a novel synthetic thrombin inhibitor (Ro 46-6240), recombinant hirudin and heparin in human plasma1994 · 43 citations