Key result
Direct antithrombins reduce venous thromboembolism in orthopedic surgery but compromise hemostasis in acute coronary syndromes, while tissue factor antagonists show a favorable preclinical profile.
Population
Patients having orthopedic surgery, acute coronary syndrome patients, and preclinical models
Comparison
Antithrombotic strategies targeting thrombin… vs Heparin or its derivatives
Design
Review
Authors
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Direct antithrombins warrant caution in ACS due to bleeding risk; leaves open clinical testing of tissue factor antagonists.
This review highlights the limitations of direct antithrombins in acute coronary syndromes due to bleeding risks and points to tissue factor antagonists and thrombin receptor inhibitors as promising future therapies.
Harker et al. (1997) conducted a review in Thrombosis. Antithrombotic strategies targeting thrombin was evaluated. Direct antithrombins reduce venous thromboembolism in orthopedic surgery but compromise hemostasis in acute coronary syndromes, while tissue factor antagonists show a favorable preclinical profile.
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