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January 1, 1994The Journal of Clinical Pharmacology

New Antithrombotic Strategies for Resistant Thrombotic Processes

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Key result

Therapies inhibiting thrombin production spare hemostasis, whereas antagonists of GPIIb/IIIa and thrombin-dependent platelet recruitment inhibit both thrombus formation and hemostatic function.

Population

Patients with atherosclerotic arterial stenoses or undergoing therapeutic thrombolytic or mechanical…

Design

Review

Authors

LHLaurence A. HarkerOpole University of Technology

Discussion

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Implication

May favor thrombin production inhibitors to preserve hemostasis; leaves open prospective validation in clinical settings.

Structured PICO

P
Population
Patients with atherosclerotic arterial stenoses or undergoing therapeutic thrombolytic or mechanical interventions (including angioplasty, atherectomies, endarterectomy, endovascular stent deployment, or implanted small caliber vascular grafts)
I
Intervention
New antithrombotic strategies including anti-GPIIb/IIIa agents, direct thrombin inhibitors, Factor Xa inhibitors, and dietary n-3 fatty acids

Inhibiting thrombin production may provide a safer antithrombotic profile by sparing hemostasis compared to direct platelet or thrombin inhibition.

Cite This Study

Laurence A. Harker (1994) conducted a review in Resistant thrombotic processes in atherosclerotic vascular disease. New antithrombotic strategies was evaluated. Therapies inhibiting thrombin production spare hemostasis, whereas antagonists of GPIIb/IIIa and thrombin-dependent platelet recruitment inhibit both thrombus formation and hemostatic function.

synapsesocial.com/papers/6a141f2ef88db7183c59c6d6https://doi.org/10.1002/j.1552-4604.1994.tb03960.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lasting safe interruption of endarterectomy thrombosis by transiently infused antithrombin peptide D-Phe-Pro-ArgCH2Cl in baboons1993 · 34 citations
  2. 2Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo.1989 · 170 citations
  3. 3Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates.1993 · 108 citations
  4. 4Role of the membrane surface in the activation of human coagulation factor X.1992 · 143 citations
  5. 5Catalytic competence of human .alpha.- and .gamma.-thrombin in the activation of fibrinogen and factor XIII1987 · 55 citations