Key result
Thrombin inhibitors, including heparin and antithrombin III, inhibited the thrombin-induced platelet reaction, though heparin did not potentiate the inhibition by antithrombin III.
Population
Human blood platelets
Design
Preclinical
Authors
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These in vitro findings should not change clinical anticoagulation; leaves open thrombin-platelet mechanisms for in vivo study.
In an in vitro model using human blood platelets, heparin and antithrombin III inhibit thrombin-induced platelet activation, though heparin does not potentiate the effect of antithrombin III.
Markwárdt et al. (2009) studied this question. Thrombin inhibitors (including heparin and antithrombin III) was evaluated on Thrombin-induced platelet reaction. Thrombin inhibitors, including heparin and antithrombin III, inhibited the thrombin-induced platelet reaction, though heparin did not potentiate the inhibition by antithrombin III.
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