Key result
Dobutamine infusion in critically ill neonates significantly increased cardiac output, with a mean threshold plasma concentration of 39 +/- 8 ng/mL and mean clearance of 90 +/- 38 mL/min/kg.
Why the study?
Does dobutamine infusion improve cardiovascular responses and what are its pharmacokinetics in critically ill neonates?
Population
13 critically ill neonates requiring inotropic support
Comparison
Dobutamine administered as a constant infusion… vs Preinfusion values (baseline)
Design
Cohort
Authors
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May support dobutamine use in neonates; hypothesis-generating for PK-guided dosing pending randomized trials.
Does dobutamine infusion improve cardiovascular responses and what are its pharmacokinetics in critically ill neonates?
Dobutamine is an effective inotropic agent for increasing cardiac output in critically ill neonates, exhibiting first-order kinetics with a mean clearance of 90 mL/min/kg.
Martinez et al. (1992) studied Critically ill neonates requiring inotropic support (n=13). Dobutamine was evaluated on Cardiac output, blood pressure, heart rate, and pharmacokinetics. Dobutamine infusion in critically ill neonates significantly increased cardiac output, with a mean threshold plasma concentration of 39 +/- 8 ng/mL and mean clearance of 90 +/- 38 mL/min/kg.
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