Key result
Irradiation of the carotid arteries with 500 rad of fast neutrons resulted in more pronounced atheromatous plaques than X-rays, whereas at 1000 rad the effect of neutrons was less extensive.
Fast neutrons induce more pronounced atheromatous plaques than X-rays at lower doses (500 rad) but less at higher doses (1000 rad) in a rabbit model, suggesting cellular damage plays a role alongside mucopolysaccharide depolymerization.
No takes yet. Share an insight, caveat, or question.
Animal data suggest neutrons may alter carotid plaque risk dose-dependently; leaves open relevance to human radiotherapy planning.
Aarnoudse et al. (1977) studied Hypercholesterolaemia (n=120). Fast neutrons (15 MeV) vs. X-rays (200 kVp) was evaluated on Atheromatous plaques. Irradiation of the carotid arteries with 500 rad of fast neutrons resulted in more pronounced atheromatous plaques than X-rays, whereas at 1000 rad the effect of neutrons was less extensive.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: