Key result
Local infusion of azepexole produced biphasic vascular responses that varied significantly by age (P=0.001) and gender (P=0.036), but not by common ADRA2B receptor polymorphisms.
Why the study?
Does azepexole infusion affect local vascular responses in healthy normotensive adults?
Does azepexole infusion affect local vascular responses in healthy normotensive adults?
Local infusion of the alpha 2-adrenergic agonist azepexole produces a biphasic vascular response in humans that is influenced by age and gender, but not by common ADRA2B genetic variants.
Authors
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Age- and gender-dependent azepexole responses are hypothesis-generating; should not change practice in patients.
KING et al. (2005) studied healthy normotensive adults (n=50). Azepexole (B-HT 933) was evaluated on dorsal hand vein vascular responses (venodilation, maximal extent of venoconstriction [Bmax], and dose producing half-maximal effect [Kd]). Local infusion of azepexole produced biphasic vascular responses that varied significantly by age (P=0.001) and gender (P=0.036), but not by common ADRA2B receptor polymorphisms.
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