Why the study?
Does HOE 234 improve bronchodilation in human airways in vitro compared to BRL 38227?
Does HOE 234 improve bronchodilation in human airways in vitro compared to BRL 38227?
HOE 234 is a potent bronchodilator that activates ATP-sensitive potassium channels in human airways in vitro, showing greater potency than BRL 38227.
HOE 234 shows greater potency in this model; leaves open translation to human airways or clinical use.
Bronchodilating effects of the novel potassium channel opener HOE 234 were examined in human bronchi in vitro and compared with those of BRL 38227. HOE 234 produced concentration-dependent relaxations of spontaneous tone and of tone increased by methacholine (10(-6) M), with mean EC50 values of 11 nM and 47 nM, respectively (n = 5). The relaxation produced by HOE 234 was 7 and 3.5 fold more potent than that by BRL 38227 on spontaneous and induced tone, respectively, and was inhibited by glibenclamide (10(-5) M). These results suggest that HOE 234 is a potent bronchodilator which activates ATP-sensitive potassium channels in human airways.
No takes yet. Share an insight, caveat, or question.
Miura et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: