Key result
Radionuclide cardiography measurements of stroke volume and LVEF correlated well with invasive techniques (r=0.83, p<0.01 for SV; r=0.93, p<0.001 for LVEF), though radionuclide LVEF was 6% lower.
Why the study?
Does non-invasive radionuclide cardiography accurately measure stroke volume and LVEF compared to invasive techniques in patients with ischemic heart disease?
Observational (n=20)
Does non-invasive radionuclide cardiography accurately measure stroke volume and LVEF compared to invasive techniques in patients with ischemic heart disease?
Radionuclide cardiography provides reliable non-invasive measurements of stroke volume and LVEF that correlate well with invasive techniques, though it yields slightly lower LVEF values than cardioangiography.
May support non-invasive SV/LVEF assessment with noted bias; leaves open prospective validation before clinical adoption.
The stroke volume (SV) was determined by first passage radionuclide cardiography and the left ventricular ejection fraction (LVEF) by multigated radionuclide cardiography in 20 patients with ischemic heart disease. the results were evaluated against those obtained by the invasive dye dilution or thermodilution and left ventricular cardioangiographic techniques. in a paired comparison the mean difference between the invasive and radionuclide SV was -1 ml (SED 3.1) with a correlation coefficient of 0.83 (p<0.01). Radionuclide LVEF values also correlated well with cardioangiographic measurements, r=0.93 (p<0.001). LVEF determined by multigated radionuclide cardiography was, however, significantly lower than when measured by cardioangiography, the mean difference being 6 per cent (p<0.001). These findings suggest that radionuclide determinations of SV and LVEF are reliable. the discrepancy between the non-invasive and invasive LVEF values raises the question, whether LVEF is overestimated by cardioangiography...
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Kelbæk et al. (1988) conducted an observational in ischemic heart disease (n=20). Radionuclide cardiography vs. Invasive dye dilution, thermodilution, and cardioangiography was evaluated on Stroke volume (SV) and left ventricular ejection fraction (LVEF) (MD -1 ml, p=<0.01). Radionuclide cardiography measurements of stroke volume and LVEF correlated well with invasive techniques (r=0.83, p<0.01 for SV; r=0.93, p<0.001 for LVEF), though radionuclide LVEF was 6% lower.
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