Key result
Gelidium amansii hot-water extract significantly decreased plasma total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol, as well as hepatic lipid accumulation in hamsters fed a high-fat diet.
Why the study?
Does Gelidium amansii hot-water extract improve lipid metabolism in hamsters fed a high-fat diet?
Does Gelidium amansii hot-water extract improve lipid metabolism in hamsters fed a high-fat diet?
Absolute Event Rate: 157.6% vs 181.3%
p-value: p=<0.05
Gelidium amansii hot-water extract ameliorates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in a hamster model, potentially via AMPK activation.
Does not support clinical use; leaves open translation of Gelidium amansii lipid effects to human hyperlipidemia.
The purpose of this study was to investigate the effects of Gelidium amansii (GA) hot-water extracts (GHE) on lipid metabolism in hamsters. Six-week-old male Syrian hamsters were used as the experimental animals. Hamsters were divided into four groups: (1) control diet group (CON); (2) high-fat diet group (HF); (3) HF with GHE diet group (HF + GHE); (4) HF with probucol diet group (HF + PO). All groups were fed the experimental diets and drinking water ad libitum for 6 weeks. The results showed that GHE significantly decreased body weight, liver weight, and adipose tissue (perirenal and paraepididymal) weight. The HF diet induced an increase in plasma triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol levels. However, GHE supplementation reversed the increase of plasma lipids caused by the HF diet. In addition, GHE increased fecal cholesterol, TG and bile acid excretion. Lower hepatic TC and TG levels were found with GHE treatment. GHE reduced hepatic sterol regulatory element-binding proteins (SREBP) including SREBP 1 and SREBP 2 protein expressions. The phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) protein expression in hamsters was decreased by the HF diet; however, GHE supplementation increased the phosphorylation of AMPK protein expression. Our results suggest that GHE may ameliorate lipid metabolism in hamsters fed a HF diet.
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Yang et al. (2017) studied Hyperlipidemia (n=32). Gelidium amansii hot-water extract (GHE) vs. High-fat diet alone was evaluated on Plasma total cholesterol (mg/dL) (p=<0.05). Gelidium amansii hot-water extract significantly decreased plasma total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol, as well as hepatic lipid accumulation in hamsters fed a high-fat diet.
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