Key result
Molecular cloning of NCC27 from the human U937 cell line revealed it as a novel chloride ion channel protein that localizes principally to the cell nucleus.
Population
Human myelomonocytic cell line U937
Design
Preclinical
Authors
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Identifies NCC27 as the first human nuclear chloride channel; leaves open its physiological role and requires functional validation.
This study identifies NCC27 as the first human member of a new class of organellar chloride ion channel proteins localized to the cell nucleus.
Valenzuela et al. (1997) studied this question. Molecular cloning and characterization of NCC27 was evaluated on Localization and characterization of NCC27. Molecular cloning of NCC27 from the human U937 cell line revealed it as a novel chloride ion channel protein that localizes principally to the cell nucleus.
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