Key result
Cl- ion channel blockers known to block NCC27 led to arrest of CHO-K1 cells in the G2/M stage of the cell cycle, supporting its role in cell cycle regulation.
Population
Chinese hamster ovary (CHO-K1) cells and PMA-activated U937 human monocyte cell line
Design
Preclinical
Authors
Loading...
NCC27 blockade may regulate cell cycle progression in vitro; leaves open any therapeutic role in proliferative disease.
The nuclear chloride ion channel NCC27 is expressed on the plasma membrane during the G2/M phase and its blockade leads to cell cycle arrest at this stage, suggesting a role in cell cycle regulation.
Valenzuela et al. (2000) studied Cell cycle regulation. Cl- ion channel blockers was evaluated on Cell cycle arrest in G2/M stage. Cl- ion channel blockers known to block NCC27 led to arrest of CHO-K1 cells in the G2/M stage of the cell cycle, supporting its role in cell cycle regulation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: