Key result
The novel Mean Platelet Volume-Age-Total Protein-Hematocrit (MAPH) score was an independent predictor of the coronary slow-flow phenomenon.
Why the study?
Coronary slow-flow phenomenon etiology is unclear but multifactorial causes affecting blood viscosity and thrombus formation are implicated; the study aimed to evaluate the novel MAPH score for predicting it.
Does the MAPH score predict the coronary slow-flow phenomenon in patients undergoing coronary angiography?
Cohort (n=266)
Does the MAPH score predict the coronary slow-flow phenomenon in patients undergoing coronary angiography?
The novel MAPH score is an independent predictor of the coronary slow-flow phenomenon, suggesting its potential utility as a marker for blood viscosity-related angiographic findings.
Answers are grounded in this paper and cite their sources.
MAPH score may aid slow-flow risk stratification on angiography; leaves open prospective validation before clinical use.
Objectives: The coronary slow-flow (CSF) phenomenon is a unique clinical angiographic entity defined as delayed coronary opacification without significant occlusive coronary artery disease.Although the etiology has not been clearly revealed, multifactorial causes that affect blood viscosity and thrombus formation are considered in the pathogenesis.We aim to investigate the usability of the novel Mean Platelet Volume-Age-Total Protein-Hematocrit (MAPH) score in predicting the CSF phenomenon. Materials and Methods:A total of 266 patients, 98 diagnosed with CSF and 168 with normal flow, were included in this retrospective cohort study.Coronary angiography images of these patients and blood samples during their hospitalization were retrospectively evaluated by two experienced cardiologists.CSF diagnosis was made according to TIMI-flow and TIMI frame-rate criteria. Results:In the analysis of the study, there were significant differences regarding age, smoking, hematocrit percentage, mean platelet volume, total protein, and MAPH score parameters (all p-values <0.01).In addition, multivariate analysis revealed that smoking, hematocrit percentage, total protein, and MAPH score parameters were independent predictors of the CSF
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Akhan et al. (2023) conducted a cohort in Coronary slow-flow phenomenon (n=266). Mean Platelet Volume-Age-Total Protein-Hematocrit (MAPH) score vs. Normal coronary flow was evaluated on Coronary slow-flow phenomenon (p=<0.01). The novel Mean Platelet Volume-Age-Total Protein-Hematocrit (MAPH) score was an independent predictor of the coronary slow-flow phenomenon.
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