Key result
Coronary slow flow is not associated with differences in mean platelet volume.
Why the study?
Is mean platelet volume (MPV) associated with coronary slow flow (CSF) in patients with stable angina pectoris and angiographically normal coronary arteries?
Cohort (n=465)
Two observers blinded to the clinical details of the individual participants independently quantified the coronary flow using the TFC
No
Is mean platelet volume (MPV) associated with coronary slow flow (CSF) in patients with stable angina pectoris and angiographically normal coronary arteries?
Absolute Event Rate: 8.73% vs 8.76%
p-value: p=.881
In patients with stable angina pectoris and angiographically normal coronary arteries, mean platelet volume is not associated with coronary slow flow, whereas height and serum uric acid levels are independent predictors of both coronary slow flow and mean TIMI frame count.
MPV is not associated with CSF in stable angina with normal coronaries; leaves open the predictive roles of height and uric acid.
OBJECTIVE: To investigate mean platelet volume (MPV) levels in patients with coronary slow flow (CSF). METHODS: 465 stable angina pectoris cases with angiographically normal coronary arteries were recruited [coronary slow flow group (n=76), control group (n=389)] in the observational retrospective cohort study. Clinical, biochemical and demographic variables including MPV were noted and coronary blood flow was assessed with TIMI frame count (TFC). RESULTS: Gender, smoking, height, serum creatinine, uric acid levels, hemoglobin, waist/hip ratio, systolic blood pressure but not MPV were significantly different among groups. Independent predictors of CSF were height (p=.029) and serum uric acid level (p=.045). Gender, height, weight, hip circumference, systolic blood pressure, fasting blood glucose, serum urea, creatinine, uric acid levels, hemoglobin and platelet count were associated with mean TFC whereas independent predictors of mean TIMI frame count were height (p=.010) and serum uric acid level (p=.041). CONCLUSION: Height and serum uric acid level but not MPV were independent predictors of both CSF and mean TFC.
No takes yet. Share an insight, caveat, or question.
Kaya et al. (2014) conducted a cohort in Stable angina pectoris with angiographically normal coronary arteries (n=465). Coronary slow flow (CSF) vs. Normal coronary blood flow (SAP without CSF) was evaluated on Mean platelet volume (MPV, fL) (p=.881). Mean platelet volume was not significantly different between patients with coronary slow flow and those with normal coronary flow (8.73±1.27 vs 8.76±1.43 fL, p=.881).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: