Key result
Extreme nocturnal blood pressure dipping did not increase cardiovascular event risk in patients <70 years (HR 0.99), but significantly increased risk in those ≥70 years (HR 1.88; 95% CI 1.14-3.11).
Why the study?
Whether extreme dipping is associated with cardiovascular events remains unclear, prompting this study to test if its prognostic role varies with age.
Does extreme nocturnal blood pressure dipping increase the risk of cardiovascular events in adults?
Cohort (n=10,868)
Yes
Does extreme nocturnal blood pressure dipping increase the risk of cardiovascular events in adults?
Hazard Ratio: 1.88 (95% CI 1.14–3.11)
p-value: p=0.013
Extreme nocturnal blood pressure dipping is associated with an increased risk of cardiovascular events only in older adults (≥70 years), exhibiting a U-shaped relationship with adverse outcomes in this age group.
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May warrant age-specific nocturnal BP monitoring in older adults; leaves open whether targeting extreme dipping improves outcomes.
Palatini et al. (2019) conducted a cohort in Cardiovascular events (n=10,868). Extreme nocturnal blood pressure dipping (>20% decline) vs. Dippers (>10%-20% decline) was evaluated on Cardiovascular events (HR 1.88, 95% CI 1.14-3.11, p=0.013). Extreme nocturnal blood pressure dipping did not increase cardiovascular event risk in patients <70 years (HR 0.99), but significantly increased risk in those ≥70 years (HR 1.88; 95% CI 1.14-3.11).
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