Why Agranulocytosis from Dapsone?

Letters, Comments and Corrections1 July 1972Why Agranulocytosis from Dapsone?W. H. JOPLING, F.R.C.P.E., D.T.M. & H.W. H. JOPLING, F.R.C.P.E., D.T.M. & H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-1-153_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Colonel Ognibene on "Agranulocytosis Due to Dapsone" is of special interest to leprologists, as dapsone has been the most widely used drug in the treatment of leprosy for the past quarter century and still holds pride of place in therapy. What particularly surprises me is that we leprologists do not encounter agranulocytosis in our patients even though, throughout the world, about 2 million persons are under treatment for leprosy at any given time, and most of these are receiving dapsone in a dosage of 50 to 100 mg/day. And yet out of an estimated...Reference1. OGNIBENE A: Agranulocytosis due to dapsone. Ann Intern Med 72:521-524. 1970 LinkGoogle Scholar1. LEIKER D: The mononucleosis syndrome in leprosy patients treated with sulfones. Int J Lepr 24:402-405, 1956 MedlineGoogle Scholar2. MCKENNA W and CHALMERS A: Agranulocytosis following dapsone therapy. Br Med J 1:324, 1958 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. H. JOPLING, F.R.C.P.E., D.T.M. & H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDapsone-associated agranulocytosis and severe anemia in a patient with leukocytoclastic vasculitisLa Dapsone dans le traitement de la maladie de Horton. Efficacité et toléranceAgranulocytosis Associated with Maloprim: Review of CasesSulphonamides and SulphonesManagement of Household Contacts of Leprosy PatientsGREGORY A. FILICE, M.D., DAVID W. FRASER, M.D.The oxidative effects of a dapson derivative on normal and chronic granulomatous disease polymorphonuclear functionAGRANULOCYTOSIS DUE TO DAPSONE 1 July 1972Volume 77, Issue 1Page: 153-153KeywordsDrug therapyLeprosy ePublished: 1 December 2008 Issue Published: 1 July 1972 PDF downloadLoading ...