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May 28, 2023Journal of Clinical MedicineOpen Access

Abdominal Aortic Aneurysm Detection in Bioelectrical Impedance Cardiovascular Screenings—A Pilot Study

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Why the study?

Current imaging for abdominal aortic aneurysm screening has limitations such as examiner dependency and ionizing radiation, prompting investigation into whether bioelectrical impedance analysis could detect aneurysms.

Does bioelectrical impedance analysis combined with machine learning accurately detect abdominal aortic aneurysms?

Population

22 patients with AAA, 16 chronic kidney disease patients, and 23 healthy controls

Comparison

Patients with AAA vs ESRD patients without AAA vs healthy controls

Design

Single-center exploratory pilot study

Key result

Bioelectrical impedance analysis using machine learning models successfully detected abdominal aortic aneurysms, with the best-performing model achieving 100% sensitivity and 100% specificity.

Authors

GHG HofmannTSTarik ShoumariyehCDChristoph Domenig

Discussion

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Overview

May support BIA-ML as a feasible non-invasive AAA detection tool; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Cross-Sectional (n=61)

Multicenter

No

Structured PICO

Does bioelectrical impedance analysis combined with machine learning accurately detect abdominal aortic aneurysms?

P
Population
61 participants including 22 patients with abdominal aortic aneurysm, 16 with end-stage renal disease, and 23 healthy controls evaluated in a single-center pilot study.
E
Exposure
Segmental bioelectrical impedance analysis (CombynECG device) combined with machine learning models
C
Comparator
Healthy controls and end-stage renal disease patients without AAA
O
Outcome
Diagnostic accuracy (sensitivity and specificity) for AAA detectionsurrogate

Main Result

Effect estimate: 100% sensitivity and 100% specificity (Model 2)

Bioelectrical impedance analysis combined with machine learning is a technically feasible and promising non-invasive tool for detecting abdominal aortic aneurysms.

Limitations

  • Limited sample size prone to introducing bias during model development
  • Missing data points due to technical issues during the measurement protocol
  • The used medical device is not specifically designed for AAA diagnostics
  • Residual confounding
  • Small sample size
  • Exploratory pilot study design

Cite This Study

Hofmann et al. (2023) conducted a cross-sectional in Abdominal Aortic Aneurysm (n=61). Bioelectrical impedance analysis (CombynECG) vs. Non-AAA controls was evaluated on Detection of abdominal aortic aneurysm (sensitivity and specificity) (100% sensitivity and 100% specificity (Model 2)). Bioelectrical impedance analysis using machine learning models successfully detected abdominal aortic aneurysms, with the best-performing model achieving 100% sensitivity and 100% specificity.

synapsesocial.com/papers/6a99a2e91939c37b084b10d8https://doi.org/10.3390/jcm12113726
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