Key result
In animal models, the blood pressure effects of macrophage depletion were highly variable, but subgroup analysis suggested the route of administration significantly influenced the effect (P<0.001).
Why the study?
Evidence suggests a role for macrophages and monocytes in hypertension, but with conflicting findings regarding whether they are protective or harmful.
Do macrophage-targeted interventions alter blood pressure in animal models?
Systematic Review (n=26)
Do macrophage-targeted interventions alter blood pressure in animal models?
Macrophage-targeted interventions have variable effects on blood pressure in preclinical models, which may depend on the route of administration and specific macrophage phenotypes.
Variable BP effects of macrophage depletion in animals caution against clinical translation; leaves open route-specific targeting for further preclinical study.
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Wenstedt et al. (2020) conducted a systematic review in Hypertension (n=26). Macrophage-targeted interventions (macrophage depletion or specific protein deletion) was evaluated on Blood pressure. In animal models, the blood pressure effects of macrophage depletion were highly variable, but subgroup analysis suggested the route of administration significantly influenced the effect (P<0.001).
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