Key result
Human parechovirus infections in neonates and infants presented with more persistent fever, irritability, feeding problems, and higher ICU admission rates compared to enterovirus infections.
Why the study?
Does human parechovirus (HPeV) infection cause more severe clinical disease compared to enterovirus (EV) infection in neonates and infants?
Population
163 neonates and infants hospitalized with suspected sepsis and positive cerebrospinal fluid polymerase…
Comparison
Human parechovirus (HPeV) infection vs Enterovirus (EV) infection
Design
Cohort
Follow-up
Up to 1 year post-infection
Authors
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May support heightened monitoring for HPeV in neonates; hypothesis-generating for differential management versus EV.
Observational
Does human parechovirus (HPeV) infection cause more severe clinical disease compared to enterovirus (EV) infection in neonates and infants?
Human parechovirus infections in neonates and infants present with greater clinical severity, including higher rates of HDU/ICU admission and lymphopenia, compared to enterovirus infections.
Black et al. (2018) conducted an observational in Enterovirus or human parechovirus infection. Human parechovirus (HPeV) infection vs. Enterovirus infection was evaluated on Clinical severity (fever, irritability, feeding problems, leukopenia, lymphopenia, ICU admission). Human parechovirus infections in neonates and infants presented with more persistent fever, irritability, feeding problems, and higher ICU admission rates compared to enterovirus infections.
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