Key result
In febrile infants <3 months, human parechovirus infection was associated with a higher rate of meeting systemic inflammatory response syndrome criteria compared to enterovirus (90.9% vs 52.9%; P=0.049).
Why the study?
What are the clinical characteristics of human parechovirus compared to enterovirus infection in febrile young infants?
Population
56 infants (<3 months) with fever without source (FWS) at a single hospital in Japan
Comparison
Human parechovirus (HPeV) infection vs Human non-polio enterovirus (EV) infection
Design
Cross-sectional
Authors
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May signal greater acuity with HPeV; hypothesis-generating for risk stratification in febrile infants <3 months.
Observational (n=56)
No
What are the clinical characteristics of human parechovirus compared to enterovirus infection in febrile young infants?
Absolute Event Rate: 90.9% vs 52.9%
p-value: p=0.049
HPeV and EV are important causes of fever without source in young infants, with HPeV presenting with distinct clinical features such as higher rates of SIRS and longer hospital stays compared to EV.
Sano et al. (2017) conducted an observational in Fever without source (FWS) (n=56). Human parechovirus (HPeV) infection vs. Human non-polio enterovirus (EV) infection was evaluated on Meeting systemic inflammatory response syndrome (SIRS) criteria (p=0.049). In febrile infants <3 months, human parechovirus infection was associated with a higher rate of meeting systemic inflammatory response syndrome criteria compared to enterovirus (90.9% vs 52.9%; P=0.049).
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