Key result
A nosocomial outbreak of human parechovirus 3 infection caused sepsis-like illness in 9 full-term newborns, all of whom recovered without long-term complications.
Observational (n=9)
No
Human parechovirus 3 should be included in the routine differential diagnosis of sepsis-like illness in newborns to prevent unnecessary antimicrobial treatment and limit nosocomial transmission.
May warrant including parechovirus 3 in newborn sepsis differentials; leaves open prospective validation of diagnostic and transmission impacts.
In 2014, sepsis-like illness affected 9 full-term newborns in 1 hospital in Austria. Although results of initial microbiological testing were negative, electron microscopy identified picornavirus. Archived serum samples and feces obtained after discharge were positive by PCR for human parechovirus 3. This infection should be included in differential diagnoses of sepsis-like illness in newborns.
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Strenger et al. (2016) conducted an observational in Sepsis-like illness due to human parechovirus 3 (HPeV3) infection (n=9). Human parechovirus 3 (HPeV3) infection was evaluated on Identification of causative pathogen and clinical characteristics. A nosocomial outbreak of human parechovirus 3 infection caused sepsis-like illness in 9 full-term newborns, all of whom recovered without long-term complications.
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