Key result
Phylogenetic analysis of a 2018 cluster of pediatric human parechovirus infections in Germany revealed co-circulation of different HPeV-3 sublineages, excluding a single-source nosocomial outbreak.
Why the study?
A cluster of pediatric human parechovirus infections was detected in 2 neighboring German hospitals in 2018, requiring investigation to understand epidemiology and outbreak origin.
Observational (n=25)
Yes
Sequence analysis of a pediatric HPeV cluster revealed co-circulation of multiple strains, ruling out a nosocomial outbreak and highlighting the importance of molecular diagnostics in outbreak investigations.
In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis demonstrated co-circulation of different HPeV-3 sublineages and of HPeV-1 and -5 strains, thereby excluding a nosocomial outbreak. Our findings underline the need for HPeV diagnostics and sequence analysis for outbreak investigations.
No takes yet. Share an insight, caveat, or question.
Elling et al. (2019) conducted an observational in Human parechovirus (HPeV) infection (n=25). Human parechovirus (HPeV) infection was evaluated on Phylogenetic clustering and clinical characteristics of HPeV cases. Phylogenetic analysis of a 2018 cluster of pediatric human parechovirus infections in Germany revealed co-circulation of different HPeV-3 sublineages, excluding a single-source nosocomial outbreak.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: