Key result
Serum ANGPTL2 levels were increased (P=0.0102) and ANGPTL3 decreased (P<0.0001) in NAFLD patients, yielding a joint area under the ROC curve of 0.773 for NAFLD prediction.
Why the study?
NAFLD is a chronic liver disease with serious public health effects, prompting investigation into relationships among ANGPTL2, ANGPTL3, and ANGPTL6 with metabolic and biochemical parameters as potential diagnostic tools.
Are serum ANGPTL2, ANGPTL3, and ANGPTL6 levels useful biomarkers for the diagnosis of non-alcoholic fatty liver disease?
Case-Control (n=103)
Are serum ANGPTL2, ANGPTL3, and ANGPTL6 levels useful biomarkers for the diagnosis of non-alcoholic fatty liver disease?
Serum ANGPTL2 and ANGPTL3 levels show potential as diagnostic biomarkers for non-alcoholic fatty liver disease.
Should not yet change NAFLD diagnostic practice; leaves open prospective validation of ANGPTL2/3 utility.
Purpose: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that has a serious effect on worldwide public health. We sought relationships among ANGPTL2, ANGPTL3, and ANGPTL6 with NAFLD metabolic and biochemical parameters, to assess their potential as diagnostic tools for NAFLD.Materials and Methods: Serum levels of ANGPTL2, ANGPTL3, and ANGPTL6 in NAFLD patients (n = 52) and non-NAFLD participants (n = 51) were quantified by ELISA. The utility of ANGPTLs as biomarkers for NAFLD prediction was assessed using receiver operating characteristic (ROC) analysis.Results: Serum ANGPTL2 levels were increased (P = 0.0102), serum ANGPTL3 levels were decreased (P < 0.0001), and ANGPTL6 levels did not change (P = 0.3174) in 52 patients with NAFLD when compared to 51 participants without NAFLD. The areas under the ROC curves for ANGPTL2 and ANGPTL3 were 0.647 and 0.746, respectively. When two factors were jointly analyzed, the area under the ROC curve for ANGPTL2 and ANGPTL3 was 0.773.Conclusion: ANGPTL2 and ANGPTL3 levels may be novel and important predictors of NAFLD severity.
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Yang et al. (2020) conducted a case-control in Nonalcoholic fatty liver disease (NAFLD) (n=103). Serum ANGPTL2 and ANGPTL3 levels vs. Non-NAFLD participants was evaluated on NAFLD prediction (Area under the ROC curve) (AUC 0.773). Serum ANGPTL2 levels were increased (P=0.0102) and ANGPTL3 decreased (P<0.0001) in NAFLD patients, yielding a joint area under the ROC curve of 0.773 for NAFLD prediction.
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