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June 22, 2020Open Access

Waist-to-hip ratio was a strong independent predictor of incident cardiovascular disease among men (HR 8.17), while diabetes, age, and other anthropometric indices predicted risk in both genders.

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Why the study?

Cardiovascular disease is the leading cause of mortality worldwide, prompting evaluation of socio-demographic, lifestyle, psychological, anthropometric, and underlying disease factors in CVD progression among Iranian adults.

Population

235 CVD patients and 8405 healthy, non-symptomatic controls

Comparison

235 CVD patients vs 8405 healthy non-symptomatic controls

Design

Cohort study

Follow-up

six years

Key result

Waist-to-hip ratio was a strong independent predictor of incident cardiovascular disease among men (HR 8.17), while diabetes, age, and other anthropometric indices predicted risk in both genders.

Authors

ZAZahra AsadiHGHamideh GhazizadehMYMahdieh Yaghooti

Discussion

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Overview

May guide sex-specific screening in Iranian adults; leaves open whether WHR improves risk models beyond standard factors.

Study Design

Type

Cohort (n=8,640)

Multicenter

No

Structured PICO

P
Population
8,640 healthy adults aged 35 to 65 years, free of cardiovascular disease at baseline, followed for 6 years to assess risk factors for incident cardiovascular events.
O
Outcome
Incidence of cardiovascular disease (corroborated by a history of myocardial infarction, angina pectoris, or electrocardiographic evidence for a definite Q wave) after six years of follow-up.hard clinical

Main Result

Hazard Ratio: 8.17 (95% CI 1.22–54.96)

p-value: p=0.031

Modifiable risk factors, particularly waist-to-hip ratio in men and metabolic syndrome/hypertension in women, are strong independent predictors of cardiovascular disease in the Iranian population.

Limitations

  • Residual unknown confounders may be present
  • Genetic and environmental factors including lifestyle characteristics and dietary habits might influence the relationships

Cite This Study

Asadi et al. (2020) conducted a cohort in Cardiovascular disease risk (n=8,640). Waist-to-hip ratio (WHR) vs. Lower waist-to-hip ratio was evaluated on Incidence of cardiovascular disease (CVD) (HR 8.17, 95% CI 1.22-54.96, p=0.031). Waist-to-hip ratio was a strong independent predictor of incident cardiovascular disease among men (HR 8.17), while diabetes, age, and other anthropometric indices predicted risk in both genders.

synapsesocial.com/papers/6a99c44d7b90230d2f39feachttps://doi.org/10.21203/rs.3.rs-35931/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of Cardiovascular Diseases Risk in the Iranian Population2021 · 1 citations
  2. 2Association between Anthropometric indices and cardiovascular disease: A cross-sectional based on Rafsanjan Cohort study2024
  3. 3The prevalence of the risk factors associated with cardiovascular diseases among Iranian adults: Findings of a cross-sectional study2024 · 1 citations
  4. 4Exploring cardiovascular disease prevalence and contributing factors among adults in Southern Iran, a cross-sectional survey: Rationale, design, and primary results2025
  5. 5How is the relationship between life style and cardiovascular diseases? A case- control study2026