Key result
Diazepam resulted in significantly less reduction in mean arterial pressure compared to propofol and etomidate during anesthesia induction in patients with left ventricular dysfunction undergoing CABG surgery.
Why the study?
Does diazepam compared to propofol and etomidate improve hemodynamic stability during anesthesia induction in patients with CAD and left ventricular dysfunction undergoing CABG?
Population
150 patients with coronary artery disease and left ventricular dysfunction scheduled for elective coronary…
Comparison
Diazepam 0.3 mg/kg intravenously for anesthesia… vs Propofol 1.5 mg/kg or Etomidate 0.2 mg/kg…
Design
RCT, Randomly allocated to three groups by the sealed envelope technique…
Follow-up
3 minutes after intubation
Authors
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Supports diazepam preference for induction in LV-dysfunction CABG; extends RCT data on induction-agent hemodynamics in cardiac surgery.
RCT (n=150)
Double-blind
Sealed envelope technique
No
Does diazepam compared to propofol and etomidate improve hemodynamic stability during anesthesia induction in patients with CAD and left ventricular dysfunction undergoing CABG?
Absolute Event Rate: -8.2% vs -26.4%
p-value: p=<0.001
Diazepam provides better hemodynamic stability compared to propofol and etomidate during anesthesia induction in CABG patients with left ventricular dysfunction.
Soleimani et al. (2017) conducted an RCT in Coronary artery disease with left ventricular dysfunction (n=150). Diazepam vs. Propofol and Etomidate was evaluated on Change in mean arterial pressure (MAP) from baseline to one minute after induction (p=<0.001). Diazepam resulted in significantly less reduction in mean arterial pressure compared to propofol and etomidate during anesthesia induction in patients with left ventricular dysfunction undergoing CABG surgery.
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