Key result
Published evidence does not show any clinically relevant effects of beta-blockers or low-dose diuretics on glucose metabolism that would restrict their use as first-line antihypertensive drugs.
Letters to the editor discussing the economic impact of hypertension guidelines, clinical trial indemnity, and the lack of evidence for a diabetogenic effect of first-line diuretics and beta-blockers.
Editor,--Recently, the World Health Organisation and International Society of Hypertension published guidelines on the management of mild hypertension. Peter H Winocour is concerned that these guidelines place too little emphasis on the impact of metabolic control on the management of essential hypertension.1 He fears that treatment with diuretics and β blockers as the first among equal agents of choice in the guidelines could lead to an 11-fold increase …
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A 1994 study conducted a letter in Hypertension. Diuretics and beta-blockers was evaluated. Published evidence does not show any clinically relevant effects of beta-blockers or low-dose diuretics on glucose metabolism that would restrict their use as first-line antihypertensive drugs.
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