Why the study?
Does selective beta 1-blockade with atenolol alter the hemodynamic response to beta 2-stimulation with terbutaline in healthy subjects?
Population
7 healthy subjects
Comparison
Infusion of selective beta 2-agonist terbutaline… vs Infusion of selective beta 2-agonist terbutaline…
Authors
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Atenolol does not fully blunt terbutaline hemodynamics in healthy subjects; leaves open beta-receptor interactions in patients.
Does selective beta 1-blockade with atenolol alter the hemodynamic response to beta 2-stimulation with terbutaline in healthy subjects?
Stimulation of beta-1 receptors plays no role in the chronotropic response and only a moderate role in the inotropic response to beta-2 agonist infusion in healthy subjects.
Strauss et al. (1986) studied this question.
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