Key result
An elevated pretreatment renin-sodium profile in hypertensive patients was significantly associated with an increased risk of fatal or nonfatal myocardial infarction compared with normal or low profiles.
Why the study?
Does an elevated renin-sodium profile increase the risk of coronary artery disease events in hypertensive patients?
Population
Hypertensive patients and a separate population of almost entirely normotensive subjects
Comparison
Highest renin-sodium profile vs Normal or low renin-sodium profiles
Design
Review
Authors
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Should not yet guide hypertension management; hypothesis-generating for renin profiling in MI risk stratification.
Cohort
Does an elevated renin-sodium profile increase the risk of coronary artery disease events in hypertensive patients?
Elevated plasma renin activity is associated with an increased risk of myocardial infarction in hypertensive patients, but not in normotensive individuals.
Michael H. Alderman (1995) conducted a cohort in Hypertension. High renin-sodium profile vs. Normal or low renin-sodium profiles was evaluated on Fatal or nonfatal myocardial infarction. An elevated pretreatment renin-sodium profile in hypertensive patients was significantly associated with an increased risk of fatal or nonfatal myocardial infarction compared with normal or low profiles.
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