Key result
New cycloalkanol derivatives of guanine failed to inhibit HSV or CMV replication in cell culture, though some showed antagonism or synergism with the protective effect of acyclovir.
New cycloalkanol derivatives of guanine do not possess direct antiviral activity against HSV or CMV in vitro, but may modulate the efficacy of acyclovir.
These derivatives lack direct anti-HSV/CMV activity; hypothesis-generating for acyclovir modulation in future studies.
New conformationaly constrained cycloalkanol derivatives of guanine have been prepared as potential anti-herpetic agents. None of these compounds was found to inhibit HSV or CMV replication in cell culture but some of them show some antagonism or synergism towards acyclovir protecting effect.
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Halazy et al. (1992) studied this question. New cycloalkanol derivatives of guanine failed to inhibit HSV or CMV replication in cell culture, though some showed antagonism or synergism with the protective effect of acyclovir.
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