Key result
LPL gene variants D9N and S447X were not significantly associated with triglyceride levels in Iranian adolescents, while HINDIII genotype distribution differed across TG categories (p=0.01-0.03).
Why the study?
Do lipoprotein lipase gene variants affect fasting triglyceride levels in Iranian adolescents?
Cross-Sectional (n=746)
Yes
Do lipoprotein lipase gene variants affect fasting triglyceride levels in Iranian adolescents?
p-value: p=0.02, 0.03, and 0.01
LPL gene variants are largely not associated with elevated triglyceride levels in Iranian adolescents, suggesting hypertriglyceridemia in this population is likely driven by lifestyle rather than genetic factors.
BACKGROUND: Lipoprotein lipase (LPL) is one of the major enzymes responsible for the hydrolysis of triglyceride (TG)-rich lipoprotein. The effects of LPL polymorphisms on serum TG are inconsistent among different populations. OBJECTIVES: This study aims to assess the TG serum concentration and distributions of three LPL single nucleotide polymorphisms (SNPs), namely D9N, HINDIII and S447X, in a nationally representative sample of Iranian adolescents. MATERIAL AND METHODS: We studied the associations between SNP genotypes and TG levels in a nationally representative sample of Iranian adolescents. Genotyping was performed in 750 randomly selected participants. We compared the genotypes according to different TG levels. RESULTS: This study comprised 746 participants, with mean ± SD age of 14.6 ± 2.5 years. The distribution of genotypes of D9N and S447X were not significantly different according to TG levels. Regarding the HINDIII polymorphism, the distribution of GG, GT, and TT genotypes were significantly different in participants with low, borderline-high, and elevated TG (p = 0.02, 0.03, and 0.01, respectively). The mean TG was not significantly different according to the genotype distribution. CONCLUSIONS: In this study, most of the LPL gene variants were not significantly different in adolescents with normal and elevated TG, and the mean TG was not different in participants with various genotypes. As the first evidence from the pediatric population of the region of the Middle East and North Africa (MENA), these results might be used in international comparisons. Our findings might suggest that the high prevalence of hypertriglyceridemia in Iranian adolescents is more likely to be a result of lifestyle rather than genetic factors.
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Kelishadi et al. (2017) conducted a cross-sectional in Hypertriglyceridemia (n=746). Lipoprotein lipase (LPL) single nucleotide polymorphisms (D9N, HINDIII, S447X) vs. Other genotypes was evaluated on Triglyceride serum concentration and distribution of LPL SNPs (p=0.02, 0.03, and 0.01). LPL gene variants D9N and S447X were not significantly associated with triglyceride levels in Iranian adolescents, while HINDIII genotype distribution differed across TG categories (p=0.01-0.03).
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