What question did this study set out to answer?

To characterize the neurochemical profile of non-Alzheimer dementia caused by lobar atrophy in comparison with Alzheimer's disease and control values.

January 1, 1993Dementia and Geriatric Cognitive Disorders

Preliminary Neurochemical Findings in Non-Alzheimer Dementia due to Lobar Atrophy

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Authors

PFPaul T. FrancisOxford Brookes University CHCourtney HolmesNational Institute of Neurological Disorders and Stroke MWMatthew T. WebsterUppsala University

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Implication

Postmortem and biopsy analysis reveals distinct cholinergic and serotonergic alterations in non-Alzheimer lobar atrophy, highlighting distinct neurochemical pathways from Alzheimer's disease.

Key Points

To characterize the neurochemical profile of non-Alzheimer dementia caused by lobar atrophy in comparison with Alzheimer's disease and control values.
Evaluated brain tissue and cerebrospinal fluid from 3 autopsy-confirmed cases of Pick's disease and 3 biopsy cases of dementia of frontal lobe type.
Assayed choline acetyltransferase activity, muscarinic cholinergic receptors, serotonin receptors, presynaptic serotonergic activity, dopamine release, and metabolic markers.
Choline acetyltransferase activities aligned with control values rather than the reduced levels characteristic of Alzheimer's disease, while muscarinic cholinergic receptors were spared only in Alzheimer's cases.
Serotonin receptors showed marked reductions in Pick's disease cases despite unchanged or elevated presynaptic serotonergic activity, alongside preserved dopamine release, inhibitory interneurons, and normal in vitro metabolism.

Cite This Study

Francis et al. (1993) studied this question.

synapsesocial.com/papers/6a99d75c1aede4d0e945a5c8 https://doi.org/10.1159/000107319

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Implication

Postmortem and biopsy analysis reveals distinct cholinergic and serotonergic alterations in non-Alzheimer lobar atrophy, highlighting distinct neurochemical pathways from Alzheimer's disease.

Preliminary Neurochemical Findings in Non-Alzheimer Dementia due to Lobar Atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

Preliminary Neurochemical Findings in Non-Alzheimer Dementia due to Lobar Atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

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