Key result
In isolated rat heart mitochondria, calcium significantly increased the reduction of NAD(P)+ with alpha-ketoglutarate or glutamate as substrates, supporting its role in regulating cardiac respiration.
Population
Isolated rat heart mitochondria
Comparison
Addition of calcium during oxidation of various… vs Absence of added calcium (Ca2+)
Design
Preclinical
Authors
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Preclinical rat mitochondria data extend Ca2+-ADP regulation of respiration; leaves open translation to in vivo human cardiac energetics.
Calcium increases mitochondrial respiration at a given level of ADP in a substrate-specific manner, supporting the hypothesis that cardiac respiration is controlled by the availability of both Ca2+ and ADP.
Panov et al. (1996) studied this question. Calcium (Ca2+) vs. Absence of Ca2+ was evaluated on Mitochondrial respiration and NAD(P)+ reduction. In isolated rat heart mitochondria, calcium significantly increased the reduction of NAD(P)+ with alpha-ketoglutarate or glutamate as substrates, supporting its role in regulating cardiac respiration.
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