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May 18, 2015Journal of Cardiovascular Disease Research

Cardiovascular Risk Factors Insulin Resistance IR, High Sensitivity C-reactive Protein (hs-CRP) and Fibrinogen in Pre- Menopausal women with Poly cystic ovarian syndrome (PCOS)

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Key result

Pre-menopausal Indian women with PCOS had greater central adiposity (waist circumference 85.82 vs 78.84 cm) and higher pro-thrombotic and pro-inflammatory factors compared to controls.

Why the study?

Do pre-menopausal Indian women with PCOS have elevated cardiovascular risk factors compared to healthy controls?

Population

150 pre-menopausal Indian women of reproductive age, comprising 100 with polycystic ovarian syndrome and 50…

Design

Case-control

Authors

PSPraveen SharmaAGAditi GuptaPPPurvi Purohit

Discussion

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Overview

Supports targeted CV risk evaluation in Indian women with PCOS; leaves open prospective outcome confirmation.

Study Design

Type

Case-Control (n=150)

Structured PICO

Do pre-menopausal Indian women with PCOS have elevated cardiovascular risk factors compared to healthy controls?

P
Population
150 pre-menopausal Indian women aged 25-45 years (100 with PCOS and 50 controls) evaluated for cardiovascular risk factors.
C
Comparator
50 healthy control women
O
Outcome
Cardiovascular risk factors including anthropometric, clinical, and biochemical parameters (insulin resistance, hs-CRP, and fibrinogen)surrogate

Main Result

Absolute Event Rate: 85.82% vs 78.84%

Pre-menopausal Indian women with PCOS exhibit increased central adiposity, insulin resistance, and pro-inflammatory factors, indicating a higher risk for future cardiovascular complications.

Cite This Study

Sharma et al. (2015) conducted a case-control in Polycystic ovarian syndrome (PCOS) (n=150). Polycystic ovarian syndrome (PCOS) vs. Controls was evaluated on Waist circumference (cm). Pre-menopausal Indian women with PCOS had greater central adiposity (waist circumference 85.82 vs 78.84 cm) and higher pro-thrombotic and pro-inflammatory factors compared to controls.

synapsesocial.com/papers/6a99d9bd819ffb2fe2b4ece2https://doi.org/10.5530/jcdr.2015.2.4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Young Obese Women with Polycystic Ovary Syndrome Have Evidence of Early Coronary Atherosclerosis2007 · 195 citations
  2. 2Polycystic ovary syndrome in the Indian Subcontinent2008 · 63 citations
  3. 3Prevalence and Impact of Metabolic Syndrome on Hospital Outcomes in Acute Myocardial Infarction2005 · 184 citations
  4. 4Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women1998 · 162 citations
  5. 5Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study<sup>1</sup>1998 · 1,520 citations