Key result
Inverted formins are a subfamily of atypical formins with unique biochemical properties and domain organization that have been linked to kidney disease and neuropathy.
This review summarizes the atypical biochemical properties and domain organization of inverted formins and their links to human diseases.
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No immediate clinical implications; leaves open validation of inverted formins as therapeutic targets in kidney disease and neuropathy.
Formins are a family of regulators of actin and microtubule dynamics that are present in almost all eukaryotes. These proteins are involved in many cellular processes, including cytokinesis, stress fiber formation, and cell polarization. Here we review one subfamily of formins, the inverted formins. Inverted formins as a group break several formin stereotypes, having atypical biochemical properties and domain organization, and they have been linked to kidney disease and neuropathy in humans. In this review, we will explore recent research on members of the inverted formin sub-family in mammals, zebrafish, fruit flies, and worms.
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Hegsted et al. (2017) conducted a review in Kidney disease and neuropathy. Inverted formins was evaluated. Inverted formins are a subfamily of atypical formins with unique biochemical properties and domain organization that have been linked to kidney disease and neuropathy.
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