What question did this study set out to answer?

To evaluate whether a positive T- and/or B-cell flow cytometric crossmatch predicts early renal allograft loss within two months in recipients with negative standard cytotoxicity crossmatches.

March 1, 1990Transplantation

The Flow Cytometric Crossmatch and Early Renal Transplant Loss

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Authors

RMRichard J. MahoneyMaine Medical Center KAKenneth A. AultGulf of Maine Research Institute SGShelley R. GivenMaine Medical Center

Discussion

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Implication

Retrospective study demonstrates that positive flow cytometric crossmatch predicts early graft loss in cadaveric kidney recipients, highlighting its value in screening sensitized candidates.

Key Points

To evaluate whether a positive T- and/or B-cell flow cytometric crossmatch predicts early renal allograft loss within two months in recipients with negative standard cytotoxicity crossmatches.
Analyzed retrospective data from 90 cadaveric kidney transplant recipients (67 primary grafts, 23 regrafts) with negative antihuman globulin complement-dependent cytotoxicity crossmatches.
Assessed two-color T- and B-cell flow cytometric crossmatch (FCXM) status, panel reactive antibody levels, and HLA mismatches, testing their association with early graft loss using stepwise logistic regression.
Graft loss within two months occurred in 33% of FCXM-positive primary grafts and 60% of FCXM-positive regrafts, compared to 7% of FCXM-negative primary grafts and 0% of FCXM-negative regrafts (P < 0.0001).
The FCXM yielded a sensitivity of 71% and a specificity of 84% for early graft loss, with an FCXM channel shift of 29 or greater associated with a 7.0-fold increased risk of early graft failure (95% CI 1.9–25.5).

Cite This Study

Mahoney et al. (1990) studied this question.

synapsesocial.com/papers/6a99f36d352e687f024d3392 https://doi.org/10.1097/00007890-199003000-00011

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March 1, 1990Transplantation

The Flow Cytometric Crossmatch and Early Renal Transplant Loss

View Full Paper

Ask AI

Bookmark

Authors

RMRichard J. MahoneyMaine Medical Center KAKenneth A. AultGulf of Maine Research Institute SGShelley R. GivenMaine Medical Center

Discussion

Member takes

Implication

Retrospective study demonstrates that positive flow cytometric crossmatch predicts early graft loss in cadaveric kidney recipients, highlighting its value in screening sensitized candidates.

Key Points

To evaluate whether a positive T- and/or B-cell flow cytometric crossmatch predicts early renal allograft loss within two months in recipients with negative standard cytotoxicity crossmatches.
Analyzed retrospective data from 90 cadaveric kidney transplant recipients (67 primary grafts, 23 regrafts) with negative antihuman globulin complement-dependent cytotoxicity crossmatches.
Assessed two-color T- and B-cell flow cytometric crossmatch (FCXM) status, panel reactive antibody levels, and HLA mismatches, testing their association with early graft loss using stepwise logistic regression.
Graft loss within two months occurred in 33% of FCXM-positive primary grafts and 60% of FCXM-positive regrafts, compared to 7% of FCXM-negative primary grafts and 0% of FCXM-negative regrafts (P < 0.0001).
The FCXM yielded a sensitivity of 71% and a specificity of 84% for early graft loss, with an FCXM channel shift of 29 or greater associated with a 7.0-fold increased risk of early graft failure (95% CI 1.9–25.5).

Cite This Study

Mahoney et al. (1990) studied this question.

synapsesocial.com/papers/6a99f36d352e687f024d3392 https://doi.org/10.1097/00007890-199003000-00011

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